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The shape of the virus is determined by its


A) nucleic acid.
B) capsid.
C) envelope.
D) tail.

E) A) and B)
F) A) and C)

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Infective and non-infective viruses may be distinguished by growth on MacConkey's agar.

A) True
B) False

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Outside of living cells, viruses are


A) scavenging glucose.
B) slowly stockpiling ATP from the mitochondria.
C) using cilia to move to the next host.
D) metabolically inert.

E) A) and B)
F) A) and C)

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During penetration of


A) lysozyme is used to allow entry of the phage capsid.
B) the tail acts as a "hypodermic needle", injecting the phage DNA into the cell.
C) the protein fibers digest a hole in the cell wall.
D) the bacterial receptor molecules open a hole through the cell wall.
E) coli by the T4 phage

F) All of the above
G) C) and E)

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The concentration of virus that infects or kills 50% of the host cells is referred to as the


A) LD50.
B) ID50.
C) ID100.
D) LD100.
E) LD50 AND ID50.

F) B) and E)
G) A) and E)

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The replicative form of nucleic acid in filamentous phages is


A) dsDNA.
B) dsRNA.
C) positive ssRNA.
D) negative ssDNA.

E) A) and B)
F) None of the above

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Why is it virtually impossible to stamp out a disease caused by a zoonotic virus?


A) You'd have to drive the vector organism extinct to do so.
B) Many vector organisms have multiple stages of their life cycle that can carry a zoonotic virus, which complicates controlling the vector-borne transmission.
C) Many viruses transmitted in this manner may utilize more than one vector organism.
D) Many zoonotic viruses may be able to reside in more than 1 host organism, complicating control measures.
E) All of the above are correct.

F) B) and E)
G) None of the above

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The structure of plant, animal and bacterial viruses are each, fundamentally, very different from one another.

A) True
B) False

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Prions


A) replicate by converting normal host proteins into prion proteins.
B) responsible for "Mad Cow Disease" can cause a similar disease in humans.
C) can be transmitted by consumption of dried or cooked food.
D) that cause Spongiform Encephalopathy have the same amino acids but different folding properties from PrPc.
E) All of the above

F) A) and B)
G) A) and C)

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All single-stranded DNA phages are extruded.

A) True
B) False

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Specialized transduction


A) involves the random transmission of any gene.
B) involves the transfer of a few specific genes.
C) utilizes a defective virus.
D) only involves genes near the viral DNA integration site.
E) involves the transfer of a few specific genes, utilizes a defective virus AND only involves genes near the viral DNA integration site.

F) D) and E)
G) C) and E)

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The time from absorption to release for T-even phage is about


A) 1 minute.
B) 10 minutes.
C) 30 minutes.
D) 1 day.

E) C) and D)
F) B) and D)

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The activation of the SOS system in a bacterium infected with a prophage results in


A) destruction of the viral genes.
B) complete lysis of the bacterial culture.
C) mutation of the DNA.
D) destruction of the viral repressor through host protease activity.
E) complete lysis of the bacterial culture AND destruction of the viral repressor through host protease activity.

F) B) and D)
G) A) and B)

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Once integrated, phage DNA can remain in the prophage state as long as


A) the bacteria is frequently plated on new media.
B) certain phage genes are excised.
C) certain phage genes are repressed.
D) bacterial repressor genes are activated.

E) C) and D)
F) A) and C)

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An exit method used by viruses which does not immediately destroy the host bacterium is


A) lysis.
B) inversion.
C) extrusion.
D) excising.

E) A) and D)
F) B) and C)

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The viral envelope closely resembles the


A) prokaryotic cell wall.
B) capsomere.
C) eukaryotic cell membrane.
D) cytoplasm.

E) A) and C)
F) A) and B)

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If the infecting phage lacks some critical pieces of DNA necessary for replication it is called


A) incomplete.
B) mutated.
C) defective.
D) vegetative.

E) A) and D)
F) All of the above

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The site at which a virus has infected and subsequently lysed the infected cell, releasing its progeny to infect and lyse surrounding cells, thereby forming a "clear zone", is referred to as


A) a burst area.
B) a lyse area.
C) a plaque.
D) a dead zone.

E) B) and D)
F) A) and D)

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The receptors to which animal virus attachment proteins usually bind are


A) proteins.
B) carbohydrates.
C) nucleic acid.
D) lipids.
E) glycoproteins.

F) A) and B)
G) A) and C)

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Phage-encoded enzymes are


A) all produced simultaneously.
B) produced in a sequential manner.
C) strictly host enzymes.
D) used to customize the cell for viral production.
E) produced in a sequential manner AND used to customize the cell for viral production.

F) A) and D)
G) C) and E)

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